Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 2248554..2249473 | Replicon | chromosome |
| Accession | NZ_CP112997 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain 2016/0386 | ||
Toxin (Protein)
| Gene name | HigB2 | Uniprot ID | L7N4R2 |
| Locus tag | ORO20_RS10560 | Protein ID | WP_003900449.1 |
| Coordinates | 2248868..2249473 (-) | Length | 202 a.a. |
Antitoxin (Protein)
| Gene name | HigA2 | Uniprot ID | L7N5K9 |
| Locus tag | ORO20_RS10555 | Protein ID | WP_003410124.1 |
| Coordinates | 2248554..2248859 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ORO20_RS10525 (ORO20_10525) | 2243565..2244821 | - | 1257 | WP_010950642.1 | HNH endonuclease signature motif containing protein | - |
| ORO20_RS10530 (ORO20_10530) | 2245175..2245750 | + | 576 | WP_031702535.1 | hypothetical protein | - |
| ORO20_RS10535 (ORO20_10535) | 2245747..2246787 | + | 1041 | WP_003410103.1 | ImmA/IrrE family metallo-endopeptidase | - |
| ORO20_RS10540 (ORO20_10540) | 2247029..2247748 | + | 720 | WP_010950643.1 | DUF433 domain-containing protein | - |
| ORO20_RS10545 (ORO20_10545) | 2247738..2248154 | + | 417 | WP_003410114.1 | hypothetical protein | - |
| ORO20_RS10550 (ORO20_10550) | 2248170..2248469 | - | 300 | WP_003410120.1 | hypothetical protein | - |
| ORO20_RS10555 (ORO20_10555) | 2248554..2248859 | - | 306 | WP_003410124.1 | XRE family transcriptional regulator | Antitoxin |
| ORO20_RS10560 (ORO20_10560) | 2248868..2249473 | - | 606 | WP_003900449.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ORO20_RS10565 (ORO20_10565) | 2249498..2249857 | - | 360 | WP_003410131.1 | hypothetical protein | - |
| ORO20_RS10570 (ORO20_10570) | 2250017..2250649 | - | 633 | WP_003913310.1 | hypothetical protein | - |
| ORO20_RS10575 (ORO20_10575) | 2250646..2250882 | - | 237 | WP_003410133.1 | hypothetical protein | - |
| ORO20_RS10580 (ORO20_10580) | 2251089..2251985 | - | 897 | WP_003410136.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 202 a.a. Molecular weight: 22744.96 Da Isoelectric Point: 7.3073
>T265076 WP_003900449.1 NZ_CP112997:c2249473-2248868 [Mycobacterium tuberculosis variant bovis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG
Download Length: 606 bp
Antitoxin
Download Length: 102 a.a. Molecular weight: 11291.91 Da Isoelectric Point: 10.7482
>AT265076 WP_003410124.1 NZ_CP112997:c2248859-2248554 [Mycobacterium tuberculosis variant bovis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA
Download Length: 306 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BV20 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BV30 |