Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-Xre |
| Location | 550909..551841 | Replicon | plasmid pSINMEB02 |
| Accession | NC_017323 | ||
| Organism | Sinorhizobium meliloti BL225C | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | H0G7T6 |
| Locus tag | SINMEB_RS27520 | Protein ID | WP_003534593.1 |
| Coordinates | 550909..551463 (-) | Length | 185 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | H0G7T7 |
| Locus tag | SINMEB_RS27525 | Protein ID | WP_003534594.1 |
| Coordinates | 551470..551841 (-) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SINMEB_RS27500 | 546441..547307 | + | 867 | WP_010975580.1 | sulfate ABC transporter permease subunit CysT | - |
| SINMEB_RS27505 | 547297..548172 | + | 876 | WP_014527285.1 | sulfate ABC transporter permease subunit CysW | - |
| SINMEB_RS27510 | 548188..549291 | + | 1104 | WP_014527286.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
| SINMEB_RS27515 | 549403..550773 | + | 1371 | WP_014527287.1 | FAD-binding oxidoreductase | - |
| SINMEB_RS27520 | 550909..551463 | - | 555 | WP_003534593.1 | RES family NAD+ phosphorylase | Toxin |
| SINMEB_RS27525 | 551470..551841 | - | 372 | WP_003534594.1 | DUF2384 domain-containing protein | Antitoxin |
| SINMEB_RS27530 | 551918..552703 | - | 786 | WP_003534600.1 | crotonase/enoyl-CoA hydratase family protein | - |
| SINMEB_RS27535 | 552700..553569 | - | 870 | WP_014527288.1 | hydroxymethylglutaryl-CoA lyase | - |
| SINMEB_RS27540 | 553566..555554 | - | 1989 | WP_014527289.1 | acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha | - |
| SINMEB_RS27545 | 555571..555954 | - | 384 | WP_010975573.1 | RidA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Mobilizable plasmid | - | htpB | 1..1690594 | 1690594 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 185 a.a. Molecular weight: 20478.39 Da Isoelectric Point: 6.6412
>T26507 WP_003534593.1 NC_017323:c551463-550909 [Sinorhizobium meliloti BL225C]
MRKRIPPASRPDPEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
MRKRIPPASRPDPEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
Download Length: 555 bp
>T26507 NC_017323:c551463-550909 [Sinorhizobium meliloti BL225C]
ATGAGGAAACGCATTCCGCCCGCATCGCGACCCGATCCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTGCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCGGCCTCATGGGTTTGA
ATGAGGAAACGCATTCCGCCCGCATCGCGACCCGATCCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTGCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCGGCCTCATGGGTTTGA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13113.26 Da Isoelectric Point: 9.9996
>AT26507 WP_003534594.1 NC_017323:c551841-551470 [Sinorhizobium meliloti BL225C]
MMAVDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
MMAVDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
Download Length: 372 bp
>AT26507 NC_017323:c551841-551470 [Sinorhizobium meliloti BL225C]
ATGATGGCCGTTGATTTCCAGATACCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA
ATGATGGCCGTTGATTTCCAGATACCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|