Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3502001..3502658 Replicon chromosome
Accession NZ_CP112980
Organism Enterobacter hormaechei subsp. xiangfangensis strain CNCI 7

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag MTX27_RS16700 Protein ID WP_015571638.1
Coordinates 3502001..3502300 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0F0ZCT3
Locus tag MTX27_RS16705 Protein ID WP_022651701.1
Coordinates 3502311..3502658 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX27_RS16690 (MTX27_16685) 3498378..3500570 + 2193 WP_222137813.1 type I secretion system permease/ATPase -
MTX27_RS16695 (MTX27_16690) 3500551..3501750 + 1200 WP_045346162.1 HlyD family efflux transporter periplasmic adaptor subunit -
MTX27_RS16700 (MTX27_16695) 3502001..3502300 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTX27_RS16705 (MTX27_16700) 3502311..3502658 + 348 WP_022651701.1 HigA family addiction module antitoxin Antitoxin
MTX27_RS16710 (MTX27_16705) 3502734..3503915 - 1182 WP_063855242.1 PLP-dependent aminotransferase family protein -
MTX27_RS16715 (MTX27_16710) 3503936..3504823 - 888 WP_032660046.1 LysR family transcriptional regulator -
MTX27_RS16720 (MTX27_16715) 3504921..3505523 + 603 WP_032660049.1 short chain dehydrogenase -
MTX27_RS16725 (MTX27_16720) 3505520..3506251 - 732 WP_222137814.1 class I SAM-dependent methyltransferase -
MTX27_RS16730 (MTX27_16725) 3506326..3507324 - 999 WP_022651706.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3483661..3529177 45516


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T264978 WP_015571638.1 NZ_CP112980:3502001-3502300 [Enterobacter hormaechei subsp. xiangfangensis]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13096.09 Da        Isoelectric Point: 9.5932

>AT264978 WP_022651701.1 NZ_CP112980:3502311-3502658 [Enterobacter hormaechei subsp. xiangfangensis]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0ZCT3

References