Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 300535..301048 Replicon chromosome
Accession NZ_CP112971
Organism Rickettsia conorii subsp. heilongjiangensis strain B8

Toxin (Protein)


Gene name yoeB Uniprot ID H6QL72
Locus tag OSR38_RS01530 Protein ID WP_012152537.1
Coordinates 300788..301048 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F3RGJ3
Locus tag OSR38_RS01525 Protein ID WP_014013992.1
Coordinates 300535..300777 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSR38_RS01505 (OSR38_01505) 295562..297331 - 1770 WP_014013988.1 ABC transporter ATP-binding protein -
OSR38_RS01510 (OSR38_01510) 297512..297781 + 270 WP_014013989.1 DUF2671 domain-containing protein -
OSR38_RS01515 (OSR38_01515) 297936..299306 + 1371 WP_267185272.1 cytochrome ubiquinol oxidase subunit I -
OSR38_RS01520 (OSR38_01520) 299314..300333 + 1020 WP_014013991.1 cytochrome d ubiquinol oxidase subunit II -
OSR38_RS01525 (OSR38_01525) 300535..300777 + 243 WP_014013992.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OSR38_RS01530 (OSR38_01530) 300788..301048 + 261 WP_012152537.1 Txe/YoeB family addiction module toxin Toxin
OSR38_RS01535 (OSR38_01535) 301041..301889 + 849 WP_267185273.1 glycosyltransferase family 2 protein -
OSR38_RS01540 (OSR38_01540) 301966..303204 + 1239 WP_267185274.1 pitrilysin family protein -
OSR38_RS01545 (OSR38_01545) 303358..304068 + 711 WP_004996420.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
OSR38_RS01550 (OSR38_01550) 304297..305883 + 1587 WP_267185275.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10314.10 Da        Isoelectric Point: 9.9572

>T264965 WP_012152537.1 NZ_CP112971:300788-301048 [Rickettsia conorii subsp. heilongjiangensis]
MYIIRYTTQAQKDAKKIVQAGLKNKVEVLLNIVSTDPWKIYPPYEKLVGDFSGCYSRRINIQHRLVYEVYKQEKVVKILR
MYTHYE

Download         Length: 261 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9405.83 Da        Isoelectric Point: 7.1617

>AT264965 WP_014013992.1 NZ_CP112971:300535-300777 [Rickettsia conorii subsp. heilongjiangensis]
MEIYNTSEARSKLYKLIDYVSDVHKPVYIKGKRNNVVIISEEDYRNMEETLYLLSIPNMHKSLIEGRAEPIAKCSDKLNW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6QL72

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3RGJ3

References