Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1018887..1019537 Replicon chromosome
Accession NZ_CP112887
Organism Raoultella electrica strain S2-IND-01-C

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OR613_RS04875 Protein ID WP_131048716.1
Coordinates 1019196..1019537 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OR613_RS04870 Protein ID WP_131048715.1
Coordinates 1018887..1019186 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OR613_RS04860 (OR613_04855) 1015302..1016036 + 735 WP_131048714.1 phosphoadenosine phosphosulfate reductase -
OR613_RS04865 (OR613_04860) 1016087..1018792 - 2706 WP_271207638.1 CRISPR-associated helicase Cas3' -
OR613_RS04870 (OR613_04865) 1018887..1019186 - 300 WP_131048715.1 helix-turn-helix transcriptional regulator Antitoxin
OR613_RS04875 (OR613_04870) 1019196..1019537 - 342 WP_131048716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OR613_RS04880 (OR613_04875) 1019892..1021427 + 1536 WP_131048717.1 type I-E CRISPR-associated protein Cse1/CasA -
OR613_RS04885 (OR613_04880) 1021405..1022046 + 642 WP_242627885.1 type I-E CRISPR-associated protein Cse2/CasB -
OR613_RS04890 (OR613_04885) 1022069..1023127 + 1059 WP_131048718.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
OR613_RS04895 (OR613_04890) 1023137..1023862 + 726 WP_131048719.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-83)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13000.60 Da        Isoelectric Point: 4.6998

>T264942 WP_131048716.1 NZ_CP112887:c1019537-1019196 [Raoultella electrica]
MWDIETTDAFDEWFEAQTGALQEDMLAAMVILSEYGPQLGRPFADTVNDSAFPNMKELRVQHQGNPIRAFFAFDPSRHGI
VLCAGDKTGLSEKRFYRDMLRLADNEYRNHLNK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11073.84 Da        Isoelectric Point: 8.6005

>AT264942 WP_131048715.1 NZ_CP112887:c1019186-1018887 [Raoultella electrica]
MSTLKELMAKQNPESRERIAEKVEELRQTIALNMLREELNISQTELAAAMGVKQPTVAKIEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References