Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4823551..4824059 Replicon chromosome
Accession NZ_CP112880
Organism Streptomyces sp. CA-278952

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag N7925_RS21705 Protein ID WP_274344875.1
Coordinates 4823551..4823811 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C4HSG8
Locus tag N7925_RS21710 Protein ID WP_050358889.1
Coordinates 4823808..4824059 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7925_RS21680 (N7925_21690) 4818789..4819163 + 375 WP_274344871.1 hypothetical protein -
N7925_RS21685 (N7925_21695) 4819330..4820205 + 876 WP_274344872.1 TatD family hydrolase -
N7925_RS21690 (N7925_21700) 4820318..4821190 + 873 WP_265601138.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
N7925_RS21695 (N7925_21705) 4821187..4822125 + 939 WP_274344873.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
N7925_RS21700 (N7925_21710) 4822207..4823541 + 1335 WP_274344874.1 acyltransferase -
N7925_RS21705 (N7925_21715) 4823551..4823811 - 261 WP_274344875.1 Txe/YoeB family addiction module toxin Toxin
N7925_RS21710 (N7925_21720) 4823808..4824059 - 252 WP_050358889.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
N7925_RS21715 (N7925_21725) 4824166..4825239 - 1074 WP_274344876.1 hypothetical protein -
N7925_RS21720 (N7925_21730) 4825236..4826369 - 1134 WP_274344877.1 hypothetical protein -
N7925_RS21725 (N7925_21735) 4826452..4827207 - 756 WP_274344878.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10353.66 Da        Isoelectric Point: 9.4413

>T264936 WP_274344875.1 NZ_CP112880:c4823811-4823551 [Streptomyces sp. CA-278952]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYTVAGDEVRIAAC
RYHYGR

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9327.42 Da        Isoelectric Point: 4.5447

>AT264936 WP_050358889.1 NZ_CP112880:c4824059-4823808 [Streptomyces sp. CA-278952]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLENGGGTVRE
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C4HSG8

References