Detailed information of TA system TA026490

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2640977..2641314
• Replicon: chromosome
• Accession: NC_017316
• Organism: Enterococcus faecalis OG1RF

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: OG1RF_RS12760
• Protein ID: WP_002381035.1
• Coordinates: 2640977..2641120 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2641052..2641314 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OG1RF_RS12735	2636097..2636312	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
OG1RF_RS12740	2636451..2637443	+	993	WP_002413308.1	biotin--[acetyl-CoA-carboxylase] ligase	-
OG1RF_RS12745	2637707..2638345	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
OG1RF_RS12755	2639031..2640647	+	1617	WP_014525060.1	phosphatase PAP2/LCP family protein	-
OG1RF_RS12760	2640977..2641120	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2641052..2641314	-	263	NuclAT_8	-	Antitoxin
-	2641264..2641313	+	50	NuclAT_10	-	-
OG1RF_RS12765	2641315..2646006	-	4692	WP_010783624.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T26490 WP_002381035.1 NC_017316:2640977-2641120 [Enterococcus faecalis OG1RF]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T26490 NC_017316:2640977-2641120 [Enterococcus faecalis OG1RF]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT26490 NC_017316:c2641314-2641052 [Enterococcus faecalis OG1RF]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin