Detailed information of TA system TA026486

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2562516..2562978
• Replicon: chromosome
• Accession: NC_017316
• Organism: Enterococcus faecalis OG1RF

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: OG1RF_RS13650
• Protein ID: WP_002392696.1
• Coordinates: 2562516..2562659 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2562824..2562978 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OG1RF_RS12410	2557810..2560554	+	2745	WP_002406717.1	glycoside hydrolase family 65 protein	-
OG1RF_RS12415	2560569..2561219	+	651	WP_002354875.1	beta-phosphoglucomutase	-
-	2561288..2561406	+	119	NuclAT_9	-	-
OG1RF_RS12420	2561682..2562275	+	594	WP_002389391.1	hypothetical protein	-
-	2562396..2562583	+	188	NuclAT_6	-	-
OG1RF_RS13650	2562516..2562659	-	144	WP_002392696.1	putative holin-like toxin	Toxin
-	2562824..2562978	+	155	NuclAT_7	-	Antitoxin
OG1RF_RS13655	2563410..2563604	+	195	Protein_2357	CPBP family intramembrane metalloprotease	-
OG1RF_RS12425	2563657..2564628	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
OG1RF_RS12430	2564803..2565240	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
OG1RF_RS12435	2565373..2565927	-	555	WP_002354869.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T26486 WP_002392696.1 NC_017316:c2562659-2562516 [Enterococcus faecalis OG1RF]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T26486 NC_017316:c2562659-2562516 [Enterococcus faecalis OG1RF]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 155 bp

>AT26486 NC_017316:2562824-2562978 [Enterococcus faecalis OG1RF]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGA
CGGTGACCATGTTAATTATTTAAAAATAACCGTGCTTGGTCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin