Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 319457..320061 Replicon chromosome
Accession NZ_CP111114
Organism Pseudomonas koreensis strain FP1691

Toxin (Protein)


Gene name higB Uniprot ID Q3KJP2
Locus tag OPS05_RS01380 Protein ID WP_011331970.1
Coordinates 319747..320061 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OPS05_RS01375 Protein ID WP_098966690.1
Coordinates 319457..319744 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPS05_RS01350 (OPS05_01350) 314587..315006 - 420 WP_232324076.1 ATP-dependent zinc protease -
OPS05_RS01355 (OPS05_01355) 315283..315690 + 408 WP_098966686.1 RNA-binding S4 domain-containing protein -
OPS05_RS01360 (OPS05_01360) 315857..316660 - 804 WP_096796730.1 phosphatase PAP2 family protein -
OPS05_RS01365 (OPS05_01365) 316766..317668 + 903 WP_098966688.1 Hsp33 family molecular chaperone HslO -
OPS05_RS01370 (OPS05_01370) 317850..319391 + 1542 WP_027611209.1 phosphoenolpyruvate carboxykinase -
OPS05_RS01375 (OPS05_01375) 319457..319744 - 288 WP_098966690.1 NadS family protein Antitoxin
OPS05_RS01380 (OPS05_01380) 319747..320061 - 315 WP_011331970.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OPS05_RS01385 (OPS05_01385) 320173..320472 - 300 WP_134785191.1 hypothetical protein -
OPS05_RS01390 (OPS05_01390) 320820..321962 - 1143 WP_134785192.1 hypothetical protein -
OPS05_RS01395 (OPS05_01395) 322055..322330 - 276 WP_098966695.1 hypothetical protein -
OPS05_RS01400 (OPS05_01400) 322633..323136 + 504 WP_134785193.1 polysaccharide deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.76 Da        Isoelectric Point: 10.3534

>T264851 WP_011331970.1 NZ_CP111114:c320061-319747 [Pseudomonas koreensis]
MIFIETRIFTRRVKELLDDDTYAAFQKQLVVSPSIGDVIEGTGGIRKTRIAAKGHGKRGGARVIYYHFVSASQIGLLMIY
PKNEQHDLSSDERKALKVLIEKWR

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10777.34 Da        Isoelectric Point: 6.8814

>AT264851 WP_098966690.1 NZ_CP111114:c319744-319457 [Pseudomonas koreensis]
MSKFFDELMESVQEMDEIVRGERTPSREFHVDALQVKEIRKATGLTQTKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAH

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q3KJP2

Antitoxin

Source ID Structure

References