Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5367167..5367762 Replicon chromosome
Accession NZ_CP111034
Organism Pseudomonas aeruginosa strain PALA50

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA50_RS24895 Protein ID WP_003113526.1
Coordinates 5367484..5367762 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA50_RS24890 Protein ID WP_003113527.1
Coordinates 5367167..5367472 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA50_RS24855 (PALA50_04937) 5362449..5362721 - 273 WP_004352675.1 hypothetical protein -
PALA50_RS24860 (PALA50_04938) 5362831..5363097 + 267 WP_023088595.1 hypothetical protein -
PALA50_RS24865 5363153..5363488 + 336 WP_043086918.1 hypothetical protein -
PALA50_RS24870 (PALA50_04939) 5363550..5364227 - 678 WP_182375736.1 hypothetical protein -
PALA50_RS24875 (PALA50_04940) 5364224..5365108 - 885 WP_073652264.1 DNA-processing protein DprA -
PALA50_RS24880 (PALA50_04941) 5365213..5366169 - 957 WP_073652263.1 hypothetical protein -
PALA50_RS24885 5366417..5366830 - 414 WP_073652262.1 hypothetical protein -
PALA50_RS24890 (PALA50_04942) 5367167..5367472 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA50_RS24895 5367484..5367762 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA50_RS24900 5367815..5367943 - 129 Protein_4918 integrase -
PALA50_RS24905 (PALA50_04943) 5368091..5370319 + 2229 WP_023086667.1 TonB-dependent receptor -
PALA50_RS24910 (PALA50_04944) 5370389..5371036 - 648 WP_003095021.1 carbonate dehydratase -
PALA50_RS24915 (PALA50_04945) 5371098..5372336 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T264835 WP_003113526.1 NZ_CP111034:c5367762-5367484 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT264835 WP_003113527.1 NZ_CP111034:c5367472-5367167 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References