Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5731795..5732390 Replicon chromosome
Accession NZ_CP111032
Organism Pseudomonas aeruginosa strain PALA54

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA54_RS26870 Protein ID WP_003113526.1
Coordinates 5732112..5732390 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA54_RS26865 Protein ID WP_003133769.1
Coordinates 5731795..5732100 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA54_RS26830 5727361..5727651 - 291 WP_023083237.1 DUF5447 family protein -
PALA54_RS26835 (PALA54_05311) 5727827..5728099 - 273 WP_004352675.1 hypothetical protein -
PALA54_RS26840 5728212..5728484 + 273 WP_034021304.1 hypothetical protein -
PALA54_RS26845 5728540..5728875 + 336 WP_025921265.1 hypothetical protein -
PALA54_RS26850 (PALA54_05313) 5729036..5730412 + 1377 WP_071534372.1 DUF3696 domain-containing protein -
PALA54_RS26855 5730409..5730891 + 483 WP_071534371.1 hypothetical protein -
PALA54_RS26860 (PALA54_05314) 5731052..5731459 - 408 WP_052151012.1 hypothetical protein -
PALA54_RS26865 (PALA54_05315) 5731795..5732100 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA54_RS26870 5732112..5732390 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA54_RS26875 5732443..5732571 - 129 Protein_5314 integrase -
PALA54_RS26880 (PALA54_05316) 5732719..5734947 + 2229 WP_043088355.1 TonB-dependent receptor -
PALA54_RS26885 (PALA54_05317) 5735018..5735665 - 648 WP_003095021.1 carbonate dehydratase -
PALA54_RS26890 (PALA54_05318) 5735727..5736965 - 1239 WP_043085810.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T264829 WP_003113526.1 NZ_CP111032:c5732390-5732112 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT264829 WP_003133769.1 NZ_CP111032:c5732100-5731795 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References