Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5016742..5017423 Replicon chromosome
Accession NZ_CP111032
Organism Pseudomonas aeruginosa strain PALA54

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA54_RS23475 Protein ID WP_015503432.1
Coordinates 5017058..5017423 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA54_RS23470 Protein ID WP_004364117.1
Coordinates 5016742..5017065 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA54_RS23440 (PALA54_04643) 5012662..5012820 + 159 WP_171945474.1 hypothetical protein -
PALA54_RS23445 (PALA54_04644) 5012904..5013299 + 396 WP_171945473.1 hypothetical protein -
PALA54_RS23450 (PALA54_04645) 5013542..5013877 + 336 WP_003140884.1 TM2 domain-containing protein -
PALA54_RS23455 (PALA54_04646) 5014051..5014569 + 519 WP_003140886.1 PAAR domain-containing protein -
PALA54_RS23460 (PALA54_04647) 5014566..5015267 + 702 WP_003111822.1 VRR-NUC domain-containing protein -
PALA54_RS23465 (PALA54_04648) 5015284..5016372 + 1089 WP_043086021.1 DUF3396 domain-containing protein -
PALA54_RS23470 (PALA54_04649) 5016742..5017065 - 324 WP_004364117.1 XRE family transcriptional regulator Antitoxin
PALA54_RS23475 5017058..5017423 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA54_RS23480 5017716..5017955 - 240 WP_044060930.1 hypothetical protein -
PALA54_RS23485 (PALA54_04650) 5018162..5018434 + 273 WP_009315277.1 hypothetical protein -
PALA54_RS23490 (PALA54_04651) 5018465..5018890 - 426 WP_033991429.1 VOC family protein -
PALA54_RS23495 (PALA54_04652) 5018990..5019874 + 885 WP_003140892.1 LysR substrate-binding domain-containing protein -
PALA54_RS23500 (PALA54_04653) 5019847..5020800 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
PALA54_RS23505 (PALA54_04654) 5021021..5021455 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5013542..5037222 23680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T264827 WP_015503432.1 NZ_CP111032:c5017423-5017058 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT264827 WP_004364117.1 NZ_CP111032:c5017065-5016742 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References