Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5688621..5689216 Replicon chromosome
Accession NZ_CP111030
Organism Pseudomonas aeruginosa strain PALA38

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA38_RS26625 Protein ID WP_003113526.1
Coordinates 5688938..5689216 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA38_RS26620 Protein ID WP_003133769.1
Coordinates 5688621..5688926 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA38_RS26585 5684187..5684477 - 291 WP_023083237.1 DUF5447 family protein -
PALA38_RS26590 (PALA38_05254) 5684653..5684925 - 273 WP_004352675.1 hypothetical protein -
PALA38_RS26595 5685038..5685310 + 273 WP_034021304.1 hypothetical protein -
PALA38_RS26600 5685366..5685701 + 336 WP_025921265.1 hypothetical protein -
PALA38_RS26605 (PALA38_05256) 5685862..5687238 + 1377 WP_071534372.1 DUF3696 domain-containing protein -
PALA38_RS26610 5687235..5687717 + 483 WP_071534371.1 hypothetical protein -
PALA38_RS26615 (PALA38_05257) 5687878..5688285 - 408 WP_052151012.1 hypothetical protein -
PALA38_RS26620 (PALA38_05258) 5688621..5688926 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA38_RS26625 5688938..5689216 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA38_RS26630 5689269..5689397 - 129 Protein_5265 integrase -
PALA38_RS26635 (PALA38_05259) 5689545..5691773 + 2229 WP_043088355.1 TonB-dependent receptor -
PALA38_RS26640 (PALA38_05260) 5691844..5692491 - 648 WP_003095021.1 carbonate dehydratase -
PALA38_RS26645 (PALA38_05261) 5692553..5693791 - 1239 WP_043085810.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T264821 WP_003113526.1 NZ_CP111030:c5689216-5688938 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT264821 WP_003133769.1 NZ_CP111030:c5688926-5688621 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References