Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4974683..4975364 Replicon chromosome
Accession NZ_CP111030
Organism Pseudomonas aeruginosa strain PALA38

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PALA38_RS23240 Protein ID WP_015503432.1
Coordinates 4974999..4975364 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA38_RS23235 Protein ID WP_004364117.1
Coordinates 4974683..4975006 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA38_RS23205 (PALA38_04589) 4970603..4970761 + 159 WP_171945474.1 hypothetical protein -
PALA38_RS23210 (PALA38_04590) 4970845..4971240 + 396 WP_171945473.1 hypothetical protein -
PALA38_RS23215 (PALA38_04591) 4971483..4971818 + 336 WP_003140884.1 TM2 domain-containing protein -
PALA38_RS23220 (PALA38_04592) 4971992..4972510 + 519 WP_003140886.1 PAAR domain-containing protein -
PALA38_RS23225 (PALA38_04593) 4972507..4973208 + 702 WP_003111822.1 VRR-NUC domain-containing protein -
PALA38_RS23230 (PALA38_04594) 4973225..4974313 + 1089 WP_043086021.1 DUF3396 domain-containing protein -
PALA38_RS23235 (PALA38_04595) 4974683..4975006 - 324 WP_004364117.1 XRE family transcriptional regulator Antitoxin
PALA38_RS23240 4974999..4975364 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA38_RS23245 4975657..4975896 - 240 WP_044060930.1 hypothetical protein -
PALA38_RS23250 (PALA38_04596) 4976103..4976375 + 273 WP_009315277.1 hypothetical protein -
PALA38_RS23255 (PALA38_04597) 4976406..4976831 - 426 WP_033991429.1 VOC family protein -
PALA38_RS23260 (PALA38_04598) 4976931..4977815 + 885 WP_003140892.1 LysR substrate-binding domain-containing protein -
PALA38_RS23265 (PALA38_04599) 4977788..4978741 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
PALA38_RS23270 (PALA38_04600) 4978962..4979396 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4971483..4977815 6332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T264819 WP_015503432.1 NZ_CP111030:c4975364-4974999 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT264819 WP_004364117.1 NZ_CP111030:c4975006-4974683 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References