Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4403996..4404598 Replicon chromosome
Accession NZ_CP111029
Organism Salmonella sp. 2018103

Toxin (Protein)


Gene name higB Uniprot ID A0A5I1G6Y9
Locus tag OLG56_RS21175 Protein ID WP_023205205.1
Coordinates 4404287..4404598 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OLG56_RS21170 Protein ID WP_000362050.1
Coordinates 4403996..4404286 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLG56_RS21155 (4401489) 4401489..4402391 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
OLG56_RS21160 (4402388) 4402388..4403023 + 636 WP_023205206.1 formate dehydrogenase cytochrome b556 subunit -
OLG56_RS21165 (4403020) 4403020..4403949 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OLG56_RS21170 (4403996) 4403996..4404286 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
OLG56_RS21175 (4404287) 4404287..4404598 - 312 WP_023205205.1 hypothetical protein Toxin
OLG56_RS21180 (4404816) 4404816..4405745 + 930 WP_001631559.1 alpha/beta hydrolase -
OLG56_RS21185 (4405831) 4405831..4406142 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
OLG56_RS21190 (4406139) 4406139..4406585 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
OLG56_RS21195 (4406600) 4406600..4407541 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OLG56_RS21200 (4407586) 4407586..4408023 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
OLG56_RS21205 (4408020) 4408020..4408892 - 873 WP_000921423.1 virulence factor BrkB family protein -
OLG56_RS21210 (4408886) 4408886..4409485 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12293.20 Da        Isoelectric Point: 8.8908

>T264812 WP_023205205.1 NZ_CP111029:c4404598-4404287 [Salmonella sp. 2018103]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMHWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT264812 WP_000362050.1 NZ_CP111029:c4404286-4403996 [Salmonella sp. 2018103]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1G6Y9

Antitoxin

Source ID Structure

References