Detailed information of TA system TA026479

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2489859..2490145
• Replicon: chromosome
• Accession: NC_017316
• Organism: Enterococcus faecalis OG1RF

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OG1RF_RS12075
• Protein ID: WP_002393909.1
• Coordinates: 2490017..2490145 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2489859..2490068 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OG1RF_RS12045	2485109..2486062	-	954	WP_002354964.1	siderophore ABC transporter substrate-binding protein	-
OG1RF_RS12050	2486101..2486856	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
OG1RF_RS12055	2486853..2487818	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
OG1RF_RS12060	2487815..2488762	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
OG1RF_RS12065	2488947..2489399	+	453	WP_002354958.1	YueI family protein	-
-	2489425..2489635	+	211	NuclAT_4	-	-
-	2489462..2489639	+	178	NuclAT_3	-	-
OG1RF_RS12070	2489584..2489711	-	128	Protein_2285	putative holin-like toxin	-
-	2489859..2490068	+	210	NuclAT_5	-	Antitoxin
-	2489893..2490072	+	180	NuclAT_2	-	-
OG1RF_RS12075	2490017..2490145	-	129	WP_002393909.1	hypothetical protein	Toxin
OG1RF_RS12080	2490308..2492578	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
OG1RF_RS12085	2492749..2493249	+	501	WP_002354954.1	cysteine hydrolase	-
OG1RF_RS12090	2493552..2494448	+	897	WP_002365354.1	YitT family protein	-
OG1RF_RS12095	2494499..2494897	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T26479 WP_002393909.1 NC_017316:c2490145-2490017 [Enterococcus faecalis OG1RF]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T26479 NC_017316:c2490145-2490017 [Enterococcus faecalis OG1RF]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 210 bp

>AT26479 NC_017316:2489859-2490068 [Enterococcus faecalis OG1RF]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin