264778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1653264..1653766 Replicon chromosome
Accession NZ_CP111008
Organism Escherichia coli strain J53-p130

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ORI87_RS07915 Protein ID WP_000767829.1
Coordinates 1653512..1653766 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ORI87_RS07910 Protein ID WP_001259255.1
Coordinates 1653264..1653515 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI87_RS07885 (1648442) 1648442..1649509 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
ORI87_RS07890 (1649509) 1649509..1650579 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
ORI87_RS07895 (1650576) 1650576..1651880 - 1305 WP_000009594.1 histidinol dehydrogenase -
ORI87_RS07900 (1651886) 1651886..1652785 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
ORI87_RS07905 (1652931) 1652931..1652981 - 51 WP_001364200.1 his operon leader peptide -
ORI87_RS07910 (1653264) 1653264..1653515 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ORI87_RS07915 (1653512) 1653512..1653766 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ORI87_RS07920 (1653849) 1653849..1654673 + 825 WP_000754737.1 SDR family oxidoreductase -
ORI87_RS07925 (1654719) 1654719..1655648 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
ORI87_RS07930 (1655863) 1655863..1655925 + 63 WP_010723108.1 membrane protein YoeI -
ORI87_RS07935 (1655915) 1655915..1657273 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ORI87_RS07940 (1657452) 1657452..1658510 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
ORI87_RS07945 (1658524) 1658524..1658751 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T264778 WP_000767829.1 NZ_CP111008:1653512-1653766 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT264778 WP_001259255.1 NZ_CP111008:1653264-1653515 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References