Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4125033..4125712 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag ORI30_RS19835 Protein ID WP_000057523.1
Coordinates 4125033..4125335 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag ORI30_RS19840 Protein ID WP_000806442.1
Coordinates 4125371..4125712 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS19815 (4120296) 4120296..4121516 - 1221 WP_001773866.1 fosmidomycin MFS transporter -
ORI30_RS19820 (4121734) 4121734..4123386 + 1653 WP_001773867.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
ORI30_RS19825 (4123423) 4123423..4123902 - 480 WP_001538397.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
ORI30_RS19830 (4124106) 4124106..4124900 - 795 WP_001538398.1 TraB/GumN family protein -
ORI30_RS19835 (4125033) 4125033..4125335 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ORI30_RS19840 (4125371) 4125371..4125712 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
ORI30_RS19845 (4125770) 4125770..4128274 - 2505 WP_000083948.1 copper-exporting P-type ATPase CopA -
ORI30_RS19850 (4128536) 4128536..4129468 + 933 WP_001538399.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T264708 WP_000057523.1 NZ_CP110996:4125033-4125335 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT264708 WP_000806442.1 NZ_CP110996:4125371-4125712 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References