Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3897280..3897974 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag ORI30_RS18790 Protein ID WP_001263500.1
Coordinates 3897576..3897974 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag ORI30_RS18785 Protein ID WP_000554758.1
Coordinates 3897280..3897573 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS18760 (3893107) 3893107..3893574 + 468 WP_000725261.1 flagellar basal body-associated FliL family protein -
ORI30_RS18765 (3893594) 3893594..3894310 + 717 WP_000938731.1 FliA/WhiG family RNA polymerase sigma factor -
ORI30_RS18770 (3894323) 3894323..3895186 + 864 WP_001169518.1 flagellar motor stator protein MotA -
ORI30_RS18775 (3895189) 3895189..3896112 + 924 WP_001532973.1 putative lateral flagellar export/assembly protein LafU -
ORI30_RS18780 (3896183) 3896183..3897228 + 1046 Protein_3665 DNA polymerase IV -
ORI30_RS18785 (3897280) 3897280..3897573 + 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
ORI30_RS18790 (3897576) 3897576..3897974 + 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
ORI30_RS18795 (3897984) 3897984..3898436 + 453 WP_001059895.1 GNAT family N-acetyltransferase -
ORI30_RS18800 (3898626) 3898626..3899765 + 1140 WP_000521561.1 RNA ligase RtcB family protein -
ORI30_RS18805 (3899762) 3899762..3900376 + 615 WP_000602124.1 peptide chain release factor H -
ORI30_RS18810 (3900433) 3900433..3901890 - 1458 WP_001292999.1 cytosol nonspecific dipeptidase -
ORI30_RS18815 (3902151) 3902151..3902609 + 459 WP_001291991.1 xanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T264706 WP_001263500.1 NZ_CP110996:3897576-3897974 [Escherichia coli]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT264706 WP_000554758.1 NZ_CP110996:3897280-3897573 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References