Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 1091350..1091582 Replicon chromosome
Accession NC_017312
Organism Enterococcus faecalis 62

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag EF62_RS16295 Protein ID WP_002355568.1
Coordinates 1091350..1091466 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 1091377..1091582 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EF62_RS05635 1086788..1089046 + 2259 WP_002363179.1 DNA helicase PcrA -
EF62_RS05640 1089172..1091202 + 2031 WP_002384934.1 NAD-dependent DNA ligase LigA -
EF62_RS16295 1091350..1091466 + 117 WP_002355568.1 putative holin-like toxin Toxin
- 1091377..1091582 - 206 - - Antitoxin
EF62_RS05650 1091784..1092089 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
EF62_RS05655 1092089..1093558 + 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
EF62_RS05660 1093558..1094988 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
EF62_RS05665 1095007..1096095 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T26470 WP_002355568.1 NC_017312:1091350-1091466 [Enterococcus faecalis 62]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

>T26470 NC_017312:1091350-1091466 [Enterococcus faecalis 62]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 206 bp

>AT26470 NC_017312:c1091582-1091377 [Enterococcus faecalis 62]
AAAAGAGAGATATGCAGGAACATACCTTTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References