Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2868447..2869049 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag ORI30_RS13785 Protein ID WP_000897302.1
Coordinates 2868447..2868758 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ORI30_RS13790 Protein ID WP_000356397.1
Coordinates 2868759..2869049 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS13755 (2863477) 2863477..2864262 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
ORI30_RS13760 (2864361) 2864361..2864960 + 600 WP_001314324.1 glucose-1-phosphatase -
ORI30_RS13765 (2864954) 2864954..2865826 + 873 WP_000920762.1 virulence factor BrkB family protein -
ORI30_RS13770 (2865823) 2865823..2866260 + 438 WP_000560978.1 D-aminoacyl-tRNA deacylase -
ORI30_RS13775 (2866305) 2866305..2867246 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
ORI30_RS13780 (2867310) 2867310..2868218 - 909 WP_001774092.1 alpha/beta hydrolase -
ORI30_RS13785 (2868447) 2868447..2868758 + 312 WP_000897302.1 hypothetical protein Toxin
ORI30_RS13790 (2868759) 2868759..2869049 + 291 WP_000356397.1 NadS family protein Antitoxin
ORI30_RS13795 (2869408) 2869408..2869686 + 279 WP_001296612.1 hypothetical protein -
ORI30_RS13800 (2870082) 2870082..2870300 + 219 WP_001314326.1 CopG family transcriptional regulator -
ORI30_RS13805 (2870516) 2870516..2871445 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
ORI30_RS13810 (2871442) 2871442..2872077 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
ORI30_RS13815 (2872074) 2872074..2872976 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T264696 WP_000897302.1 NZ_CP110996:2868447-2868758 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT264696 WP_000356397.1 NZ_CP110996:2868759-2869049 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References