Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1918248..1918941 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag ORI30_RS09195 Protein ID WP_000415584.1
Coordinates 1918645..1918941 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ORI30_RS09190 Protein ID WP_000650107.1
Coordinates 1918248..1918643 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS09180 (1914112) 1914112..1916370 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
ORI30_RS09185 (1916508) 1916508..1918115 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
ORI30_RS09190 (1918248) 1918248..1918643 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
ORI30_RS09195 (1918645) 1918645..1918941 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
ORI30_RS09200 (1919146) 1919146..1919628 - 483 WP_000183505.1 GyrI-like domain-containing protein -
ORI30_RS09205 (1919681) 1919681..1920073 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
ORI30_RS09210 (1920225) 1920225..1920884 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
ORI30_RS09215 (1920881) 1920881..1922230 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
ORI30_RS09220 (1922276) 1922276..1922608 - 333 WP_000917685.1 DUF2645 family protein -
ORI30_RS09225 (1922927) 1922927..1923508 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
ORI30_RS09230 (1923539) 1923539..1923853 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1909785..1918941 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T264693 WP_000415584.1 NZ_CP110996:c1918941-1918645 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT264693 WP_000650107.1 NZ_CP110996:c1918643-1918248 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References