Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 787171..787673 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag ORI30_RS04010 Protein ID WP_000767822.1
Coordinates 787171..787425 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ORI30_RS04015 Protein ID WP_001259255.1
Coordinates 787422..787673 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS03990 (783664) 783664..785022 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
ORI30_RS03995 (785012) 785012..785074 - 63 WP_010723108.1 membrane protein YoeI -
ORI30_RS04000 (785289) 785289..786218 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
ORI30_RS04005 (786264) 786264..787088 - 825 WP_000754737.1 SDR family oxidoreductase -
ORI30_RS04010 (787171) 787171..787425 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ORI30_RS04015 (787422) 787422..787673 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ORI30_RS04020 (787956) 787956..788006 + 51 WP_001364200.1 his operon leader peptide -
ORI30_RS04025 (788152) 788152..789051 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
ORI30_RS04030 (789057) 789057..790361 + 1305 WP_001445483.1 histidinol dehydrogenase -
ORI30_RS04035 (790358) 790358..791428 + 1071 WP_001538918.1 histidinol-phosphate transaminase -
ORI30_RS04040 (791428) 791428..792495 + 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T264690 WP_000767822.1 NZ_CP110996:c787425-787171 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT264690 WP_001259255.1 NZ_CP110996:c787673-787422 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References