Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 219673..220235 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag ORI30_RS01065 Protein ID WP_000605675.1
Coordinates 219957..220235 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag ORI30_RS01060 Protein ID WP_000781370.1
Coordinates 219673..219957 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS01045 (214854) 214854..217901 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
ORI30_RS01050 (217914) 217914..218798 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
ORI30_RS01055 (218791) 218791..219444 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
ORI30_RS01060 (219673) 219673..219957 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
ORI30_RS01065 (219957) 219957..220235 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ORI30_RS01070 (220421) 220421..221431 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
ORI30_RS01075 (221565) 221565..223262 - 1698 WP_000433460.1 malate dehydrogenase -
ORI30_RS01080 (223419) 223419..223556 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
ORI30_RS01085 (223658) 223658..223873 - 216 WP_000495766.1 biofilm-dependent modulation protein -
ORI30_RS01090 (224218) 224218..224649 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T264685 WP_000605675.1 NZ_CP110996:c220235-219957 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT264685 WP_000781370.1 NZ_CP110996:c219957-219673 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References