Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3782600..3783141 Replicon chromosome
Accession NZ_CP110988
Organism Escherichia coli strain XYEH3314

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag ORI32_RS18435 Protein ID WP_000615979.1
Coordinates 3782863..3783141 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag ORI32_RS18430 Protein ID WP_000729704.1
Coordinates 3782600..3782860 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI32_RS18410 (3778275) 3778275..3779060 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
ORI32_RS18415 (3779032) 3779032..3780744 + 1713 Protein_3606 flagellar biosynthesis protein FlhA -
ORI32_RS18420 (3780968) 3780968..3781465 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
ORI32_RS18425 (3781641) 3781641..3782414 - 774 WP_123297815.1 C40 family peptidase -
ORI32_RS18430 (3782600) 3782600..3782860 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ORI32_RS18435 (3782863) 3782863..3783141 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ORI32_RS18440 (3783297) 3783297..3784037 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
ORI32_RS18445 (3784008) 3784008..3784775 - 768 WP_000333379.1 class II glutamine amidotransferase -
ORI32_RS18450 (3784981) 3784981..3785559 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T264679 WP_000615979.1 NZ_CP110988:3782863-3783141 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT264679 WP_000729704.1 NZ_CP110988:3782600-3782860 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References