Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 637497..638296 Replicon chromosome
Accession NZ_CP110988
Organism Escherichia coli strain XYEH3314

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag ORI32_RS03070 Protein ID WP_000347251.1
Coordinates 637497..637961 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag ORI32_RS03075 Protein ID WP_001308975.1
Coordinates 637961..638296 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI32_RS03040 (632498) 632498..632932 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
ORI32_RS03045 (632950) 632950..633828 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
ORI32_RS03050 (633818) 633818..634597 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
ORI32_RS03055 (634608) 634608..635081 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
ORI32_RS03060 (635104) 635104..636384 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
ORI32_RS03065 (636633) 636633..637442 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
ORI32_RS03070 (637497) 637497..637961 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ORI32_RS03075 (637961) 637961..638296 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ORI32_RS03080 (638445) 638445..640016 - 1572 WP_064221457.1 galactarate dehydratase -
ORI32_RS03085 (640391) 640391..641725 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
ORI32_RS03090 (641741) 641741..642511 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T264663 WP_000347251.1 NZ_CP110988:c637961-637497 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT264663 WP_001308975.1 NZ_CP110988:c638296-637961 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References