Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3691012..3691553 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag ORI33_RS17800 Protein ID WP_000615979.1
Coordinates 3691275..3691553 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag ORI33_RS17795 Protein ID WP_000729704.1
Coordinates 3691012..3691272 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS17780 (3687065) 3687065..3689158 + 2094 WP_021570012.1 flagellar biosynthesis protein FlhA -
ORI33_RS17785 (3689374) 3689374..3689871 - 498 WP_000006261.1 REP-associated tyrosine transposase RayT -
ORI33_RS17790 (3690047) 3690047..3690826 - 780 WP_266058004.1 C40 family peptidase -
ORI33_RS17795 (3691012) 3691012..3691272 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ORI33_RS17800 (3691275) 3691275..3691553 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ORI33_RS17805 (3691709) 3691709..3692449 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
ORI33_RS17810 (3692420) 3692420..3693187 - 768 WP_000333379.1 class II glutamine amidotransferase -
ORI33_RS17815 (3693393) 3693393..3693971 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 3690047..3704293 14246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T264656 WP_000615979.1 NZ_CP110978:3691275-3691553 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT264656 WP_000729704.1 NZ_CP110978:3691012-3691272 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References