Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2421029..2421667 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ORI33_RS11660 Protein ID WP_000813794.1
Coordinates 2421491..2421667 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ORI33_RS11655 Protein ID WP_001270286.1
Coordinates 2421029..2421445 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS11635 (2416181) 2416181..2417122 - 942 WP_001251315.1 ABC transporter permease -
ORI33_RS11640 (2417123) 2417123..2418136 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
ORI33_RS11645 (2418154) 2418154..2419299 - 1146 WP_266057217.1 ABC transporter substrate-binding protein -
ORI33_RS11650 (2419544) 2419544..2420950 - 1407 WP_095885713.1 PLP-dependent aminotransferase family protein -
ORI33_RS11655 (2421029) 2421029..2421445 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ORI33_RS11660 (2421491) 2421491..2421667 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ORI33_RS11665 (2421889) 2421889..2422119 + 231 WP_000494244.1 YncJ family protein -
ORI33_RS11670 (2422211) 2422211..2424172 - 1962 WP_001515270.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ORI33_RS11675 (2424245) 2424245..2424781 - 537 WP_000429150.1 DNA-binding transcriptional regulator SutR -
ORI33_RS11680 (2424873) 2424873..2426048 + 1176 WP_231708907.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2426088..2427236 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T264651 WP_000813794.1 NZ_CP110978:c2421667-2421491 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT264651 WP_001270286.1 NZ_CP110978:c2421445-2421029 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References