Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 725195..725888 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag ORI33_RS03515 Protein ID WP_000415584.1
Coordinates 725195..725491 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ORI33_RS03520 Protein ID WP_000650107.1
Coordinates 725493..725888 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS03480 (720283) 720283..720597 - 315 WP_000958598.1 putative quinol monooxygenase -
ORI33_RS03485 (720628) 720628..721209 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
ORI33_RS03490 (721528) 721528..721860 + 333 WP_096310111.1 DUF2645 family protein -
ORI33_RS03495 (721906) 721906..723255 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
ORI33_RS03500 (723252) 723252..723911 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
ORI33_RS03505 (724063) 724063..724455 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
ORI33_RS03510 (724508) 724508..724990 + 483 WP_266058901.1 GyrI-like domain-containing protein -
ORI33_RS03515 (725195) 725195..725491 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
ORI33_RS03520 (725493) 725493..725888 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
ORI33_RS03525 (726021) 726021..727628 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
ORI33_RS03530 (727766) 727766..730024 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T264642 WP_000415584.1 NZ_CP110978:725195-725491 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT264642 WP_000650107.1 NZ_CP110978:725493-725888 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References