Detailed information of TA system TA026463

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 324836..325173
• Replicon: chromosome
• Accession: NC_017312
• Organism: Enterococcus faecalis 62

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: EF62_RS01595
• Protein ID: WP_002381035.1
• Coordinates: 324836..324979 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	324911..325173 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EF62_RS01570	320935..321564	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
EF62_RS01580	322257..323873	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
EF62_RS01585	324203..324346	+	144	WP_002392818.1	type I toxin-antitoxin system toxin PepG1	-
EF62_RS01590	324465..324605	+	141	WP_073340360.1	putative holin-like toxin	-
EF62_RS01595	324836..324979	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	324911..325173	-	263	-	-	Antitoxin
EF62_RS01600	325174..329865	-	4692	WP_010819042.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T26463 WP_002381035.1 NC_017312:324836-324979 [Enterococcus faecalis 62]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T26463 NC_017312:324836-324979 [Enterococcus faecalis 62]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT26463 NC_017312:c325173-324911 [Enterococcus faecalis 62]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin