Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4938414..4939060 Replicon chromosome
Accession NZ_CP110941
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1873/18

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag NPY10_RS24560 Protein ID WP_002920560.1
Coordinates 4938713..4939060 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NPY10_RS24555 Protein ID WP_002920557.1
Coordinates 4938414..4938713 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY10_RS24535 (NPY10_24535) 4934620..4935378 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
NPY10_RS24540 (NPY10_24540) 4935428..4936258 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NPY10_RS24545 (NPY10_24545) 4936309..4936638 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NPY10_RS24550 (NPY10_24550) 4936843..4938351 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NPY10_RS24555 (NPY10_24555) 4938414..4938713 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NPY10_RS24560 (NPY10_24560) 4938713..4939060 - 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPY10_RS24565 (NPY10_24565) 4939236..4941683 - 2448 WP_002920561.1 glycogen phosphorylase -
NPY10_RS24570 (NPY10_24570) 4941701..4943134 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T264553 WP_002920560.1 NZ_CP110941:c4939060-4938713 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT264553 WP_002920557.1 NZ_CP110941:c4938713-4938414 [Klebsiella pneumoniae subsp. pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References