Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4558391..4558993 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag ORG43_RS22330 Protein ID WP_001159630.1
Coordinates 4558682..4558993 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ORG43_RS22325 Protein ID WP_000362050.1
Coordinates 4558391..4558681 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS22310 (4555884) 4555884..4556786 + 903 WP_001541228.1 formate dehydrogenase subunit beta -
ORG43_RS22315 (4556783) 4556783..4557418 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
ORG43_RS22320 (4557415) 4557415..4558344 + 930 WP_001541226.1 formate dehydrogenase accessory protein FdhE -
ORG43_RS22325 (4558391) 4558391..4558681 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
ORG43_RS22330 (4558682) 4558682..4558993 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
ORG43_RS22335 (4559211) 4559211..4560126 + 916 Protein_4362 alpha/beta hydrolase -
ORG43_RS22340 (4560140) 4560140..4561081 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
ORG43_RS22345 (4561126) 4561126..4561563 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
ORG43_RS22350 (4561560) 4561560..4562432 - 873 WP_023235429.1 virulence factor BrkB family protein -
ORG43_RS22355 (4562426) 4562426..4563025 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T264523 WP_001159630.1 NZ_CP110934:c4558993-4558682 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT264523 WP_000362050.1 NZ_CP110934:c4558681-4558391 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References