Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2361114..2361676 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5QCT4
Locus tag OQW59_RS14225 Protein ID WP_003836234.1
Coordinates 2361114..2361392 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B5QC60
Locus tag OQW59_RS14230 Protein ID WP_003836231.1
Coordinates 2361392..2361676 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS14205 (2356231) 2356231..2356662 - 432 WP_003020036.1 peroxiredoxin OsmC -
OQW59_RS14210 (2356890) 2356890..2357030 + 141 WP_003020039.1 stationary-phase-induced ribosome-associated protein -
OQW59_RS14215 (2357210) 2357210..2358907 + 1698 WP_003836239.1 malate dehydrogenase -
OQW59_RS14220 (2359217) 2359217..2360932 + 1716 WP_148373683.1 ABC-F family ATP-binding cassette domain-containing protein -
OQW59_RS14225 (2361114) 2361114..2361392 + 279 WP_003836234.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OQW59_RS14230 (2361392) 2361392..2361676 + 285 WP_003836231.1 HigA family addiction module antitoxin Antitoxin
OQW59_RS14235 (2361720) 2361720..2362322 - 603 WP_032935729.1 inorganic diphosphatase -
OQW59_RS14240 (2362452) 2362452..2363108 - 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
OQW59_RS14245 (2363101) 2363101..2363985 - 885 WP_003833024.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10637.28 Da        Isoelectric Point: 9.8965

>T264471 WP_003836234.1 NZ_CP110894:2361114-2361392 [Citrobacter freundii]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGDRDGIWAIAVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10358.10 Da        Isoelectric Point: 8.8094

>AT264471 WP_003836231.1 NZ_CP110894:2361392-2361676 [Citrobacter freundii]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQTTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5QCT4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5QC60

References