Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 246174..246637 Replicon chromosome
Accession NC_017312
Organism Enterococcus faecalis 62

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag EF62_RS01215 Protein ID WP_002392696.1
Coordinates 246174..246317 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 246493..246637 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EF62_RS01195 241515..244259 + 2745 WP_002406717.1 glycosyl hydrolase family 65 protein -
EF62_RS01200 244274..244924 + 651 WP_002354875.1 beta-phosphoglucomutase -
EF62_RS01205 245339..245857 + 519 WP_002354874.1 PBECR4 domain-containing protein -
EF62_RS01215 246174..246317 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 246493..246637 + 145 - - Antitoxin
EF62_RS01220 247097..247261 + 165 WP_224567316.1 hypothetical protein -
EF62_RS01225 247314..248285 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
EF62_RS01230 248460..248897 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
EF62_RS01235 249030..249584 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T26447 WP_002392696.1 NC_017312:c246317-246174 [Enterococcus faecalis 62]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T26447 NC_017312:c246317-246174 [Enterococcus faecalis 62]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 145 bp

>AT26447 NC_017312:246493-246637 [Enterococcus faecalis 62]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References