Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4772862..4773464 Replicon chromosome
Accession NZ_CP110873
Organism Enterobacter kobei strain SCLZS19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OQE50_RS23145 Protein ID WP_047624626.1
Coordinates 4773153..4773464 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B2XUJ3
Locus tag OQE50_RS23140 Protein ID WP_032635182.1
Coordinates 4772862..4773152 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQE50_RS23125 (4770360) 4770360..4771262 + 903 WP_008501831.1 formate dehydrogenase subunit beta -
OQE50_RS23130 (4771259) 4771259..4771894 + 636 WP_008501832.1 formate dehydrogenase cytochrome b556 subunit -
OQE50_RS23135 (4771891) 4771891..4772820 + 930 WP_047343709.1 formate dehydrogenase accessory protein FdhE -
OQE50_RS23140 (4772862) 4772862..4773152 - 291 WP_032635182.1 NadS family protein Antitoxin
OQE50_RS23145 (4773153) 4773153..4773464 - 312 WP_047624626.1 hypothetical protein Toxin
OQE50_RS23150 (4773693) 4773693..4774613 + 921 WP_047624625.1 alpha/beta hydrolase -
OQE50_RS23155 (4774622) 4774622..4775563 - 942 WP_023336483.1 fatty acid biosynthesis protein FabY -
OQE50_RS23160 (4775608) 4775608..4776045 - 438 WP_014885747.1 D-aminoacyl-tRNA deacylase -
OQE50_RS23165 (4776042) 4776042..4776923 - 882 WP_014885748.1 virulence factor BrkB family protein -
OQE50_RS23170 (4776917) 4776917..4777516 - 600 WP_045268693.1 glucose-1-phosphatase -
OQE50_RS23175 (4777636) 4777636..4778436 - 801 WP_014885750.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12215.24 Da        Isoelectric Point: 10.2130

>T264423 WP_047624626.1 NZ_CP110873:c4773464-4773153 [Enterobacter kobei]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLVTQPNNGDLIQNTGGLRKIRWFSGSKGKRGGVRVIYFHRTREFEIRLLLIY
RKGIKDDLSAKEKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10703.22 Da        Isoelectric Point: 10.5888

>AT264423 WP_032635182.1 NZ_CP110873:c4773152-4772862 [Enterobacter kobei]
MDKALFERLTQSIAQMNEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B2XUJ3

References