Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1193716..1194365 Replicon chromosome
Accession NZ_CP110873
Organism Enterobacter kobei strain SCLZS19

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0PLQ3
Locus tag OQE50_RS05720 Protein ID WP_014882864.1
Coordinates 1194003..1194365 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag OQE50_RS05715 Protein ID WP_014882863.1
Coordinates 1193716..1194015 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQE50_RS05705 (1190141) 1190141..1192114 + 1974 WP_193970167.1 PhoX family phosphatase -
OQE50_RS05710 (1192217) 1192217..1193605 + 1389 WP_014882862.1 phenylalanine transporter -
OQE50_RS05715 (1193716) 1193716..1194015 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
OQE50_RS05720 (1194003) 1194003..1194365 - 363 WP_014882864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OQE50_RS05725 (1194571) 1194571..1195806 + 1236 WP_193970166.1 MFS transporter -
OQE50_RS05730 (1195822) 1195822..1196847 + 1026 WP_248188303.1 sugar phosphate isomerase/epimerase -
OQE50_RS05735 (1196840) 1196840..1197982 + 1143 WP_252072273.1 Gfo/Idh/MocA family oxidoreductase -
OQE50_RS05740 (1198058) 1198058..1199029 + 972 WP_014882868.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13952.92 Da        Isoelectric Point: 6.7114

>T264415 WP_014882864.1 NZ_CP110873:c1194365-1194003 [Enterobacter kobei]
MWNVETTDRFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGNKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT264415 WP_014882863.1 NZ_CP110873:c1194015-1193716 [Enterobacter kobei]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PLQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References