264405

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3531991..3532532 Replicon chromosome
Accession NZ_CP110859
Organism Escherichia coli strain TSW4881-W1

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag OQ464_RS17355 Protein ID WP_000615983.1
Coordinates 3532254..3532532 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag OQ464_RS17350 Protein ID WP_000729703.1
Coordinates 3531991..3532251 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQ464_RS17330 (3527666) 3527666..3528451 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
OQ464_RS17335 (3528423) 3528423..3530135 + 1713 Protein_3387 flagellar biosynthesis protein FlhA -
OQ464_RS17340 (3530359) 3530359..3530856 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
OQ464_RS17345 (3531032) 3531032..3531781 - 750 WP_000056849.1 C40 family peptidase -
OQ464_RS17350 (3531991) 3531991..3532251 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OQ464_RS17355 (3532254) 3532254..3532532 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OQ464_RS17360 (3532688) 3532688..3533428 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OQ464_RS17365 (3533399) 3533399..3534166 - 768 WP_012305459.1 class II glutamine amidotransferase -
OQ464_RS17370 (3534372) 3534372..3534950 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T264405 WP_000615983.1 NZ_CP110859:3532254-3532532 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT264405 WP_000729703.1 NZ_CP110859:3531991-3532251 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References