Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 36832..37562 Replicon chromosome
Accession NZ_CP110857
Organism Enterobacter hormaechei strain K432

Toxin (Protein)


Gene name higB Uniprot ID A0A837FIL2
Locus tag OQO37_RS00170 Protein ID WP_023302825.1
Coordinates 36832..37146 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OQO37_RS00175 Protein ID WP_032620773.1
Coordinates 37146..37562 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQO37_RS00150 (OQO37_00150) 32498..33583 + 1086 Protein_29 cellulase family glycosylhydrolase -
OQO37_RS00155 (OQO37_00155) 33489..34673 - 1185 WP_015570118.1 multidrug efflux MFS transporter EmrD -
OQO37_RS00160 (OQO37_00160) 34849..35682 - 834 WP_032620535.1 DMT family transporter -
OQO37_RS00165 (OQO37_00165) 35745..36191 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
OQO37_RS00170 (OQO37_00170) 36832..37146 + 315 WP_023302825.1 type II toxin-antitoxin system HigB family toxin Toxin
OQO37_RS00175 (OQO37_00175) 37146..37562 + 417 WP_032620773.1 helix-turn-helix domain-containing protein Antitoxin
OQO37_RS00180 (OQO37_00180) 37709..37807 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
OQO37_RS00185 (OQO37_00185) 37914..39602 + 1689 WP_023302827.1 acetolactate synthase large subunit -
OQO37_RS00190 (OQO37_00190) 39606..39893 + 288 WP_015570113.1 acetolactate synthase small subunit -
OQO37_RS00195 (OQO37_00195) 40019..40612 + 594 WP_003861054.1 transcriptional regulator UhpA -
OQO37_RS00200 (OQO37_00200) 40609..42114 + 1506 WP_032634219.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12415.51 Da        Isoelectric Point: 10.2825

>T264375 WP_023302825.1 NZ_CP110857:36832-37146 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15249.77 Da        Isoelectric Point: 5.2068

>AT264375 WP_032620773.1 NZ_CP110857:37146-37562 [Enterobacter hormaechei]
MIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANGPEIVALRKEMESVPVGI
AVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FIL2

Antitoxin

Source ID Structure

References