Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3904174..3904586 Replicon chromosome
Accession NZ_CP110816
Organism Escherichia coli strain THB42-F5

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag N0566_RS19065 Protein ID WP_000132601.1
Coordinates 3904245..3904586 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3904174..3904250 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0566_RS19055 (3901037) 3901037..3902626 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
N0566_RS19060 (3902623) 3902623..3904017 + 1395 WP_072647344.1 type I restriction-modification system specificity subunit -
- (3904174) 3904174..3904250 - 77 NuclAT_14 - Antitoxin
- (3904174) 3904174..3904250 - 77 NuclAT_14 - Antitoxin
- (3904174) 3904174..3904250 - 77 NuclAT_14 - Antitoxin
- (3904174) 3904174..3904250 - 77 NuclAT_14 - Antitoxin
- (3904174) 3904174..3904250 - 77 NuclAT_15 - Antitoxin
- (3904174) 3904174..3904250 - 77 NuclAT_15 - Antitoxin
- (3904174) 3904174..3904250 - 77 NuclAT_15 - Antitoxin
- (3904174) 3904174..3904250 - 77 NuclAT_15 - Antitoxin
N0566_RS19065 (3904245) 3904245..3904586 + 342 WP_000132601.1 endoribonuclease SymE Toxin
N0566_RS19070 (3904748) 3904748..3906127 + 1380 WP_072647343.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
N0566_RS19075 (3906127) 3906127..3907173 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T264345 WP_000132601.1 NZ_CP110816:3904245-3904586 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT264345 NZ_CP110816:c3904250-3904174 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References