264322

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 122849..123118 Replicon plasmid pHB42-F4
Accession NZ_CP110815
Organism Escherichia coli strain THB42-F4

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag N0552_RS23055 Protein ID WP_001372321.1
Coordinates 122993..123118 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 122849..122914 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0552_RS23020 117851..118312 - 462 Protein_132 hypothetical protein -
N0552_RS23025 118614..119141 + 528 WP_000290834.1 single-stranded DNA-binding protein -
N0552_RS23030 119199..119432 + 234 WP_000006003.1 DUF905 family protein -
N0552_RS23035 119493..121461 + 1969 Protein_135 ParB/RepB/Spo0J family partition protein -
N0552_RS23040 121530..121964 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
N0552_RS23045 121961..122723 + 763 Protein_137 plasmid SOS inhibition protein A -
- 122692..122916 + 225 NuclAT_0 - -
- 122692..122916 + 225 NuclAT_0 - -
- 122692..122916 + 225 NuclAT_0 - -
- 122692..122916 + 225 NuclAT_0 - -
- 122849..122914 - 66 - - Antitoxin
N0552_RS23050 122902..123051 + 150 Protein_138 plasmid maintenance protein Mok -
N0552_RS23055 122993..123118 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
N0552_RS23060 123437..123733 - 297 Protein_140 hypothetical protein -
N0552_RS23065 124033..124329 + 297 WP_001272251.1 hypothetical protein -
N0552_RS23070 124440..125261 + 822 WP_001234445.1 DUF932 domain-containing protein -
N0552_RS23075 125558..126205 - 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
N0552_RS23080 126482..126865 + 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
N0552_RS23085 127056..127742 + 687 WP_015059009.1 PAS domain-containing protein -
N0552_RS23090 127836..128063 + 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / mph(A) / blaTEM-1B / rmtB / aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaCTX-M-55 - 1..162755 162755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T264322 WP_001372321.1 NZ_CP110815:122993-123118 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp


Antitoxin


Download         Length: 66 bp

>AT264322 NZ_CP110815:c122914-122849 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References