Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3904285..3904697 Replicon chromosome
Accession NZ_CP110814
Organism Escherichia coli strain THB42-F4

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag N0552_RS19055 Protein ID WP_000132601.1
Coordinates 3904356..3904697 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3904285..3904361 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0552_RS19045 (3901148) 3901148..3902737 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
N0552_RS19050 (3902734) 3902734..3904128 + 1395 WP_072647344.1 type I restriction-modification system specificity subunit -
- (3904285) 3904285..3904361 - 77 NuclAT_14 - Antitoxin
- (3904285) 3904285..3904361 - 77 NuclAT_14 - Antitoxin
- (3904285) 3904285..3904361 - 77 NuclAT_14 - Antitoxin
- (3904285) 3904285..3904361 - 77 NuclAT_14 - Antitoxin
- (3904285) 3904285..3904361 - 77 NuclAT_15 - Antitoxin
- (3904285) 3904285..3904361 - 77 NuclAT_15 - Antitoxin
- (3904285) 3904285..3904361 - 77 NuclAT_15 - Antitoxin
- (3904285) 3904285..3904361 - 77 NuclAT_15 - Antitoxin
N0552_RS19055 (3904356) 3904356..3904697 + 342 WP_000132601.1 endoribonuclease SymE Toxin
N0552_RS19060 (3904859) 3904859..3906238 + 1380 WP_072647343.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
N0552_RS19065 (3906238) 3906238..3907284 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-71)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T264313 WP_000132601.1 NZ_CP110814:3904356-3904697 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp


Antitoxin


Download         Length: 77 bp

>AT264313 NZ_CP110814:c3904361-3904285 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9YSY7


Antitoxin

Download structure file

References