Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 717335..718028 Replicon chromosome
Accession NZ_CP110814
Organism Escherichia coli strain THB42-F4

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N0552_RS03495 Protein ID WP_000415584.1
Coordinates 717335..717631 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N0552_RS03500 Protein ID WP_000650107.1
Coordinates 717633..718028 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0552_RS03460 (712423) 712423..712737 - 315 WP_000958598.1 putative quinol monooxygenase -
N0552_RS03465 (712768) 712768..713349 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
N0552_RS03470 (713668) 713668..714000 + 333 WP_000917684.1 DUF2645 family protein -
N0552_RS03475 (714046) 714046..715395 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
N0552_RS03480 (715392) 715392..716051 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
N0552_RS03485 (716203) 716203..716595 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N0552_RS03490 (716648) 716648..717130 + 483 WP_000183505.1 GyrI-like domain-containing protein -
N0552_RS03495 (717335) 717335..717631 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N0552_RS03500 (717633) 717633..718028 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N0552_RS03505 (718161) 718161..719768 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
N0552_RS03510 (719906) 719906..722164 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T264295 WP_000415584.1 NZ_CP110814:717335-717631 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT264295 WP_000650107.1 NZ_CP110814:717633-718028 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References