Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1696946..1697460 Replicon chromosome
Accession NZ_CP110798
Organism Limosilactobacillus fermentum strain BRD_L14

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag OP867_RS08695 Protein ID WP_265707939.1
Coordinates 1696946..1697209 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag OP867_RS08700 Protein ID WP_003684069.1
Coordinates 1697206..1697460 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP867_RS08670 (OP867_08670) 1692795..1693235 - 441 WP_075667502.1 KxYKxGKxW signal peptide domain-containing protein -
OP867_RS08675 (OP867_08675) 1693427..1693843 - 417 Protein_1663 IS256 family transposase -
OP867_RS08680 (OP867_08680) 1693999..1694679 - 681 WP_265707938.1 IS30 family transposase -
OP867_RS08685 (OP867_08685) 1694783..1694908 + 126 Protein_1665 zinc ribbon domain-containing protein -
OP867_RS08690 (OP867_08690) 1695415..1696536 + 1122 WP_023465987.1 PTS sugar transporter subunit IIC -
OP867_RS08695 (OP867_08695) 1696946..1697209 - 264 WP_265707939.1 Txe/YoeB family addiction module toxin Toxin
OP867_RS08700 (OP867_08700) 1697206..1697460 - 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OP867_RS08705 (OP867_08705) 1697622..1698287 - 666 Protein_1669 family 1 glycosylhydrolase -
OP867_RS08710 (OP867_08710) 1698538..1699197 - 660 WP_004562986.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
OP867_RS08715 (OP867_08715) 1699748..1700068 - 321 WP_262335471.1 hypothetical protein -
OP867_RS08720 (OP867_08720) 1700073..1700429 - 357 WP_004562984.1 MmcQ/YjbR family DNA-binding protein -
OP867_RS08725 (OP867_08725) 1700431..1701078 - 648 WP_265707940.1 sel1 repeat family protein -
OP867_RS08730 (OP867_08730) 1701207..1702175 - 969 WP_023465990.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1686144..1705340 19196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10293.99 Da        Isoelectric Point: 10.0702

>T264266 WP_265707939.1 NZ_CP110798:c1697209-1696946 [Limosilactobacillus fermentum]
MSYAIELKRSANKELKKIKGLYLEKSFLQIIEQLRKDPLAPNQGFEKLVLPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHDE

Download         Length: 264 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT264266 WP_003684069.1 NZ_CP110798:c1697460-1697206 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References