264245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1909521..1910851 Replicon chromosome
Accession NZ_CP110790
Organism Yersinia massiliensis strain SCPM-O-B-8026 (C-146)

Toxin (Protein)


Gene name HipT Uniprot ID A0A2R4NNK4
Locus tag OP862_RS08490 Protein ID WP_050286363.1
Coordinates 1909521..1910543 (-) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0T9T098
Locus tag OP862_RS08495 Protein ID WP_050079781.1
Coordinates 1910540..1910851 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP862_RS08475 (OP862_08475) 1905732..1907156 + 1425 WP_167311297.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
OP862_RS08480 (OP862_08480) 1907324..1908298 + 975 WP_050286361.1 chemotaxis protein -
OP862_RS08485 (OP862_08485) 1908531..1909313 + 783 WP_050286362.1 SDR family oxidoreductase -
OP862_RS08490 (OP862_08490) 1909521..1910543 - 1023 WP_050286363.1 HipA domain-containing protein Toxin
OP862_RS08495 (OP862_08495) 1910540..1910851 - 312 WP_050079781.1 HipA N-terminal domain-containing protein Antitoxin
OP862_RS08500 (OP862_08500) 1910836..1911180 - 345 WP_050079780.1 hypothetical protein -
OP862_RS08505 (OP862_08505) 1911547..1912161 + 615 WP_050079779.1 TetR/AcrR family transcriptional regulator -
OP862_RS08510 (OP862_08510) 1912236..1913345 + 1110 WP_050878790.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38276.09 Da        Isoelectric Point: 6.9755

>T264245 WP_050286363.1 NZ_CP110790:c1910543-1909521 [Yersinia massiliensis]
MNPEHCLINLSRLKGAELKTGYSTKGIRHLFGRLEVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEGGELMVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFEIPPFGLIAFKRDDNRSDELAFVIKRYDRLGADIMRLHQEQLDGAMG
LGDKYGNIDNKKAISYEKAAKFLNKSVSSSLKSMRDVFLRIVYAYILGNNDFHLRNFGIIHPEKGSSYLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAASAPGLDSAYGEYLGADFILLAQGIGINPVLAKKWLTDVIKSHQLIIDTYTESHMPEAQ
REAVLKYVARRITLLAVTEL

Download         Length: 1023 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11748.64 Da        Isoelectric Point: 6.9762

>AT264245 WP_050079781.1 NZ_CP110790:c1910851-1910540 [Yersinia massiliensis]
MARKIGVWLYNKPVGTLSEEDIGFAFCYLANYTGRPISLSMPIRPEPYINQELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMQNGNDLLGAVVLKEITS

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R4NNK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9T098

References