Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1292345..1293014 Replicon chromosome
Accession NZ_CP110789
Organism Yersinia intermedia strain SCPM-O-B-10209 (333)

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OP861_RS05815 Protein ID WP_050084850.1
Coordinates 1292345..1292692 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OP861_RS05820 Protein ID WP_050084851.1
Coordinates 1292697..1293014 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP861_RS05790 (OP861_05790) 1287919..1288335 - 417 WP_074000306.1 DUF2502 domain-containing protein -
OP861_RS05795 (OP861_05795) 1288493..1289482 - 990 WP_265535709.1 aldo/keto reductase -
OP861_RS05800 (OP861_05800) 1289609..1290493 - 885 WP_050084847.1 LysR family transcriptional regulator -
OP861_RS05805 (OP861_05805) 1290596..1291072 + 477 WP_050133193.1 multidrug/biocide efflux PACE transporter -
OP861_RS05810 (OP861_05810) 1291249..1292214 + 966 WP_265535710.1 glucokinase -
OP861_RS05815 (OP861_05815) 1292345..1292692 + 348 WP_050084850.1 toxin Toxin
OP861_RS05820 (OP861_05820) 1292697..1293014 + 318 WP_050084851.1 transcriptional regulator Antitoxin
OP861_RS05825 (OP861_05825) 1293040..1294284 - 1245 WP_241916199.1 OFA family MFS transporter -
OP861_RS05830 (OP861_05830) 1294508..1295248 - 741 WP_050133197.1 LytTR family DNA-binding domain-containing protein -
OP861_RS05835 (OP861_05835) 1295252..1296952 - 1701 WP_005183692.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-88)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13688.04 Da        Isoelectric Point: 9.9631

>T264233 WP_050084850.1 NZ_CP110789:1292345-1292692 [Yersinia intermedia]
MDAVFVELPSFERLRFEYLSDDEYRSLQIMLMNNPMIGDVIQQTGGLRKMRFSDPRRGKGKRGGVRVIYYWWVERLQFLL
FTLYSKGEMTDLTETQRKILGDLLKCRKAELTLLR

Download         Length: 348 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12010.69 Da        Isoelectric Point: 9.5118

>AT264233 WP_050084851.1 NZ_CP110789:1292697-1293014 [Yersinia intermedia]
MKKRDLFSELLEGMDAWQDANTGKKTLKTHKVSGESSVTLTADELRHIRETLNISQALFAHYLQAGTATYQNWEQGRAKP
NKQAILLIRMVQRDPHTLQTLAELY

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References