Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2117098..2117611 Replicon chromosome
Accession NZ_CP110784
Organism Staphylococcus capitis strain CCSM0123

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4U9TK67
Locus tag OP858_RS10380 Protein ID WP_002452576.1
Coordinates 2117345..2117611 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B5RQB4
Locus tag OP858_RS10375 Protein ID WP_002452575.1
Coordinates 2117098..2117352 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP858_RS10355 (OP858_10355) 2113086..2113253 + 168 WP_002452554.1 hypothetical protein -
OP858_RS10360 (OP858_10360) 2113904..2114092 - 189 WP_074839874.1 hypothetical protein -
OP858_RS10365 (OP858_10365) 2115816..2116174 + 359 Protein_2008 replication protein -
OP858_RS10370 (OP858_10370) 2116828..2116950 - 123 Protein_2009 plasmid recombination protein -
OP858_RS10375 (OP858_10375) 2117098..2117352 + 255 WP_002452575.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OP858_RS10380 (OP858_10380) 2117345..2117611 + 267 WP_002452576.1 Txe/YoeB family addiction module toxin Toxin
OP858_RS10385 (OP858_10385) 2118224..2118772 - 549 WP_267263446.1 recombinase family protein -
OP858_RS10390 (OP858_10390) 2118860..2119255 - 396 WP_267263447.1 arsenate reductase (thioredoxin) -
OP858_RS10395 (OP858_10395) 2119272..2120564 - 1293 WP_016898840.1 arsenite efflux transporter membrane subunit ArsB -
OP858_RS10400 (OP858_10400) 2120564..2120878 - 315 WP_002452589.1 metalloregulator ArsR/SmtB family transcription factor -
OP858_RS10405 (OP858_10405) 2120875..2122539 - 1665 WP_049390943.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2044260..2128636 84376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10510.19 Da        Isoelectric Point: 10.1215

>T264226 WP_002452576.1 NZ_CP110784:2117345-2117611 [Staphylococcus capitis]
MNKYNVTFTPTAFEDYKYWQTQDKKLLKKINSLIKSIQRNGILEGEGKPEPLKGNLKGYYSRRMNHEHRLVYTIKDPSII
IIACRYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9651.68 Da        Isoelectric Point: 4.1237

>AT264226 WP_002452575.1 NZ_CP110784:2117098-2117352 [Staphylococcus capitis]
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDRNAVLISEDDYNSIMETLYLQQSPVNAKRLAQSMEEAERVNTVEVDI
TTYE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9TK67

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RQB4

References