Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 267618..268137 Replicon chromosome
Accession NZ_CP110784
Organism Staphylococcus capitis strain CCSM0123

Toxin (Protein)


Gene name yoeB Uniprot ID A0A507SVT5
Locus tag OP858_RS01180 Protein ID WP_002436254.1
Coordinates 267618..267887 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1J4EAU6
Locus tag OP858_RS01185 Protein ID WP_002436168.1
Coordinates 267880..268137 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP858_RS01160 (OP858_01160) 262649..264559 + 1911 WP_267263590.1 YSIRK-type signal peptide-containing protein -
OP858_RS01165 (OP858_01165) 264673..265431 + 759 WP_002454143.1 alpha/beta hydrolase family protein -
OP858_RS01170 (OP858_01170) 265897..267045 + 1149 Protein_230 CapA family protein -
OP858_RS01175 (OP858_01175) 267109..267474 - 366 WP_002454140.1 DUF4870 domain-containing protein -
OP858_RS01180 (OP858_01180) 267618..267887 - 270 WP_002436254.1 Txe/YoeB family addiction module toxin Toxin
OP858_RS01185 (OP858_01185) 267880..268137 - 258 WP_002436168.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OP858_RS01190 (OP858_01190) 268322..269179 + 858 WP_267263506.1 ABC transporter substrate-binding protein -
OP858_RS01195 (OP858_01195) 269294..270934 - 1641 WP_002454138.1 alpha-keto acid decarboxylase family protein -
OP858_RS01200 (OP858_01200) 271107..271562 + 456 WP_002454137.1 MarR family transcriptional regulator -
OP858_RS01205 (OP858_01205) 271935..272684 + 750 WP_029625748.1 hypothetical protein -
OP858_RS01210 (OP858_01210) 272579..272836 - 258 WP_016898538.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10524.00 Da        Isoelectric Point: 9.7885

>T264219 WP_002436254.1 NZ_CP110784:c267887-267618 [Staphylococcus capitis]
MSKFSVTFTAQAFKDYQYWQQHNQNYFKKVNALLKSIARDGCVDGIGKPEALKGNYEGYFSRRVSIEHRLIYKIKDDSIF
VVSCRFHYQ

Download         Length: 270 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9737.79 Da        Isoelectric Point: 4.1359

>AT264219 WP_002436168.1 NZ_CP110784:c268137-267880 [Staphylococcus capitis]
MPSVNYSNARQNFKELITKVNEDSVAYTITTKENENAVILAEKDYNAMLETMYLQSNLANVSHLNQSIMELNHNQTITIE
IDDNE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SVT5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4EAU6

References