Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2903556..2904222 Replicon chromosome
Accession NZ_CP110775
Organism Citrobacter freundii strain Cf-Emp

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag OPR78_RS14585 Protein ID WP_003847996.1
Coordinates 2903556..2903873 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag OPR78_RS14590 Protein ID WP_003837894.1
Coordinates 2903926..2904222 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPR78_RS14570 (2898726) 2898726..2899604 + 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -
OPR78_RS14575 (2899714) 2899714..2901432 - 1719 WP_047715944.1 DUF4153 domain-containing protein -
OPR78_RS14580 (2901811) 2901811..2903433 + 1623 WP_044701411.1 phosphoenolpyruvate carboxykinase (ATP) -
OPR78_RS14585 (2903556) 2903556..2903873 + 318 WP_003847996.1 hypothetical protein Toxin
OPR78_RS14590 (2903926) 2903926..2904222 + 297 WP_003837894.1 NadS family protein Antitoxin
OPR78_RS14595 (2904279) 2904279..2905631 - 1353 WP_275269332.1 two-component system sensor histidine kinase EnvZ -
OPR78_RS14600 (2905628) 2905628..2906347 - 720 WP_001157751.1 two-component system response regulator OmpR -
OPR78_RS14605 (2906573) 2906573..2907046 + 474 WP_003023524.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T264206 WP_003847996.1 NZ_CP110775:2903556-2903873 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT264206 WP_003837894.1 NZ_CP110775:2903926-2904222 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References