Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3801992..3802659 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag OO115_RS17840 Protein ID WP_003417916.1
Coordinates 3801992..3802384 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag OO115_RS17845 Protein ID WP_003912214.1
Coordinates 3802384..3802659 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS17820 (OO115_17820) 3797839..3798828 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
OO115_RS17825 (OO115_17825) 3798828..3799217 - 390 Protein_3521 polyprenyl synthetase family protein -
OO115_RS17830 (OO115_17830) 3799270..3800531 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
OO115_RS17835 (OO115_17835) 3800573..3801238 - 666 Protein_3523 polyprenyl synthetase family protein -
OO115_RS17840 (OO115_17840) 3801992..3802384 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
OO115_RS17845 (OO115_17845) 3802384..3802659 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OO115_RS17850 (OO115_17850) 3802841..3804212 + 1372 Protein_3526 ISNCY family transposase -
OO115_RS17855 (OO115_17855) 3804402..3806579 + 2178 WP_016330440.1 PE family protein -
OO115_RS17860 (OO115_17860) 3806650..3807522 - 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3799270..3804212 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T264186 WP_003417916.1 NZ_CP110674:c3802384-3801992 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT264186 WP_003912214.1 NZ_CP110674:c3802659-3802384 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References