Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2038005..2038924 Replicon chromosome
Accession NZ_CP110674
Organism Mycobacterium tuberculosis strain BLR-31d

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag OO115_RS09395 Protein ID WP_003900449.1
Coordinates 2038319..2038924 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag OO115_RS09390 Protein ID WP_003410124.1
Coordinates 2038005..2038310 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO115_RS09355 (OO115_09355) 2033268..2033468 + 201 Protein_1855 hypothetical protein -
OO115_RS09365 (OO115_09365) 2034824..2035201 + 378 Protein_1857 hypothetical protein -
OO115_RS09370 (OO115_09370) 2035198..2036238 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
OO115_RS09375 (OO115_09375) 2036480..2037199 + 720 WP_003410108.1 DUF433 domain-containing protein -
OO115_RS09380 (OO115_09380) 2037189..2037605 + 417 WP_003410114.1 hypothetical protein -
OO115_RS09385 (OO115_09385) 2037621..2037920 - 300 WP_003410120.1 hypothetical protein -
OO115_RS09390 (OO115_09390) 2038005..2038310 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
OO115_RS09395 (OO115_09395) 2038319..2038924 - 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO115_RS09400 (OO115_09400) 2038949..2039308 - 360 WP_003410131.1 hypothetical protein -
OO115_RS09405 (OO115_09405) 2039468..2040058 - 591 WP_223695536.1 hypothetical protein -
OO115_RS09410 (OO115_09410) 2040097..2040333 - 237 WP_003410133.1 hypothetical protein -
OO115_RS09415 (OO115_09415) 2040540..2041436 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T264156 WP_003900449.1 NZ_CP110674:c2038924-2038319 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT264156 WP_003410124.1 NZ_CP110674:c2038310-2038005 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References